For any ride over an hour I normally apply a layer of thin cream called "chamois cream" between my chamois and skin. The reasoning is to keep friction low between chamois and body, as well as skin to skin.
women’s chamois butter
A popular question after cycling shorts and saddle recommendations is normally about chamois cream. If you haven’t heard about it before, don’t feel too left out it basically is under carriage lube. Wait what? Yes, a cream you put between you and the shorts. Why do I need Chamois Cream? I go through spurts...